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Virus may be cancer killer – Calif. biotech report

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Scientists at a California biotech company on Thursday said that a relatively harmless common virus may turn out to be a cancer killer.

Preliminary human safety trials are under way on the experimental therapy developed by Frank McCormick and colleagues at ONYX Pharmaceuticals Inc, a biotech company in Richmond, California. A report on the potential therapy appears in Friday’s edition of the journal Science.

Earlier experiments on mice yielded promising results, but many therapies that seem promising on small-scale animal studies turn out to be frustratingly ineffective or have intolerable side effects in humans.

The research uses a modified version of a common adenovirus, which causes mild respiratory infections in humans.

“In the very simplest terms, the virus is being modified so its ability to replicate and grow in normal cells is severely impaired, but it can still grow productively in cancer cells,” McCormick said in a telephone interview. Once it gets in the cancer cells, the hope is that it will kill them.

“We want to destroy the tumour from the inside,” said McCormick, ONYX’s chief scientific officer.

In the human trials that began several months ago, the modified virus was injected in human head and neck cancers, areas where scientists can easily track the progress of the virus through biopsies.

The hope is that the altered virus can penetrate the tumour, killing cells that lack healthy p53 genes, but leaving normal cells untouched.

Sometimes called the “guardian of the genome,” P53 is a tumour suppressor gene. A normal p53 produces a protein that controls cell growth and division. But when p53 is missing or defective, cells grow wildly, picking up more mutations and forming tumours. Those tumours tend to be the ones that are hardest to treat with chemotherapy or radiation.

When an adenovirus infects a cell, it hijacks the cell’s genetic machinery, using a protein called E1B 55k that blocks p53. Once p53 is inactivated, the virus can turn the cell into a factory for producing more virus.

The genetically altered version does not produce E1B 55K. Therefore, it does not interfere with cells that have healthy normal p53 genes. But in tumour cells where p53 has already been inactivated, the virus can take over and kill the cell.

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Health news: What does it take for mental health?

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Health news: What does it take for mental health?

As important as physical health has become in the post-coronavirus world, so has the need for mental health.

New Delhi: As important as physical health has become in the post-Corona world, experts strongly express the need to maintain mental health. Because during the Corona period, people all over the world suffered from various mental illnesses. We are currently living in a different era. You think you should be present everywhere. You have to be connected with everyone. But social networks have made us antisocial, doing more damage than we expected. This is especially true of your mental health.

Meditation is important when it comes to taking care of mental health. Meditation is very easy. If you are interested in learning to meditate, there are many apps. But if your mind cannot concentrate or the confusion in your mind does not subside, then various hobbies should be taken up. There are many options for drawing, knitting, reading books, cooking.

What do you need

It is important to avoid spending too much time on social media. Need to meditate and exercise daily. Concentration can also be gained through reading books. Hobbies increase mental strength.

Website title: health mental health physical health meaning mental health experts citizens ysh

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Lip care tips: make your lips rosy and soft, do this home remedy

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Lip care tips: make your lips rosy and soft, do this home remedy

Lips enhance facial beauty. Lips give your face a complete look. Nowadays people like thick lips. Here are some home remedies for you.

lip care
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Pink and plump lips: Lips enhance facial beauty. Lips give your face a complete look. Nowadays people like thick lips. Therefore, surgery is also performed. But this surgery is very expensive. At the same time, many women undergo surgery. Surgery in such cases can also be dangerous. In such cases, home remedies can be used instead of surgery.

Do this with soft pink lips.

Clove oil
You can soften your lips using clove oil. Some care should be taken when using this oil. Always use clove oil in lip balm. You can also use it by adding 1 teaspoon of clove oil in honey.

Apply moisturizer on the lips.
You can apply moisturizer to make your lips look more beautiful. This will prevent your lips from chapping and will also keep them moisturized. You can also use lip balm for this. This will keep the moisture on your lips and make your lips look very attractive.

menthol trick
You can use the menthol trick on your lips to make them look plumper. This will not harm your lips in any way. Also, your lips will look very soft and pretty.

Cinnamon
You can also use cinnamon oil for the skin on your lips. When you apply cinnamon oil on your lips, it can get a bit irritated and your lips get swollen. In such cases, never apply cinnamon oil directly on the lips. To apply cinnamon oil to your lips, first mix lip balm or Vaseline and then apply it to your lips.

(Note: The information provided here is based on folk remedies and general information. Before adopting, please be sure to consult a doctor.)

Website title: Lip care tips, follow these home remedies to make a rosy and plump prp.

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Don’t do ‘this’ work on the train after 10pm; Otherwise, action can be taken

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Don’t do ‘this’ work on the train after 10pm; Otherwise, action can be taken

Your trip can be more comfortable if every passenger on the train follows the rules of the train.

railway rules
(File photo: Financial Express)

Most of the people in the country love to travel by train. Traveling by train is comfortable and safe. In such cases, you must know all the rules related to railways. The railways establish various rules for the comfort of the passengers. In recent days, the Railway Board has also changed a number of rules for passenger comfort. Your trip can be more comfortable if every passenger on the train follows the rules of the train. Today we will learn some rules related to railways, with which you can make your trip more comfortable.

The middle berth was the most difficult to travel in a tri-level coach. Often the bottom bunk passenger stays in the seat late into the night, so the middle bunk passenger cannot relax despite her wishes. It also happens that middle bunk passengers sit on the bottom bunk late into the night, making it difficult for the bottom bunk passenger to sleep.

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If this has ever happened to you, you may not know the rules of the train. But from now on you can check the rules of the railways. According to railway regulations, you can open the middle bunk from 10:00 p.m. to 6:00 a.m. That is, if you have a lower berth, a passenger in the middle or upper berth cannot sit in his seat after 10 pm You can ask him to go to his seat, referring to the railway rules. In addition, even if a passenger with a middle bunk opens his seat during the day, you can deny it by stating this railway rule.

Many passengers complain that the train TCs arrive late at night to check tickets. In such a situation, your sleep is disturbed. To alleviate this problem and facilitate passenger travel, TC cannot check tickets between 22:00 and 06:00 according to railway regulations. But if your trip starts after 10 p.m., this rail rule does not apply.

A five-year-old girl gave birth to a baby boy; You will be surprised to read the incident.

Complaints from passengers who listen to songs at full volume or watch videos on their mobiles at night reach the Railway Board from passengers. In this context, the railways have banned listening to songs or watching videos without headphones after 10 p.m. As a general rule, after 22:00 you cannot listen to songs or watch videos without headphones. Not only this, it is also forbidden to talk loudly at night.

If your traveling companion does not listen to you, you can complain to the train staff present on the train. It is the responsibility of the railway staff to go to the place and solve your problem. If the passenger still does not agree, then he can be treated according to the rules of the railways.

Website title: Do not do these things on the train after 10 pm, otherwise pvp action can be taken

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